Health concerns in the large breeds which are sometimes found in the Spanish Mastiff include hip dysplasia, heart problems and Entropies (inversion of the eye lids). Also pano-ostiosis (growing pains), which occurs when they are growing puppies. This breed is also prone to bloat. It is wise to feed the Spanish Mastiff several small meals rather than one big one. Births are difficult in some Spanish Mastiffs and C-sections are often needed.